When Dr. Alex Reid (Erica Durance) gets a call that her alarm is going off, she arrives home to an unexpected surprise. Then, with one of the participants in her cancer trial with Dr. Maggie Lin (Julia Taylor Ross) not responding to medication, Alex and Maggie are forced to turn to Dr. Charlie Harris (Michael Shanks), the newly-appointed Chief of Surgery, for his opinion when they can't agree on a method of treatment.
Meanwhile, Dr. Zach Miller (Benjamin Ayres) is reluctantly transitioning the E.R. to an Urgent Care facility, until a patient who challenges societal conventions persuades Zach not to settle for second best.