AceShowbiz -

"House M.D." will take a two-week worth of break and return with "Known Unknowns" in the second week of November. Similarly, Cuddy, Wilson and House spend a weekend away from the hospital to attend a medical conference, but things don't go as planned when House's private investigator, Lucas, returns.

In the medical case, a teenage girl is brought to Princeton Plainsboro with severely swollen appendages after a wild night out. The team must work to diagnose the young girl, who is less than honest about what happened the night she fell ill. As her condition worsens, she becomes unable to distinguish fact from fiction.

Anna Lucia Attanasio guest stars as the teenage girl while Michael Weston returns to reprise his role as Lucas.

EW reported on Monday, October 19 that "NCIS: Naval Criminal Investigative Service" alumna Sasha Alexander is coming to "House" in an episode airing either late December or early January. She will be a gorgeous neighbor that comes in between House and Wilson when the house-mates move into a new neighborhood.