St Trinian's, the infamous school for 'young ladies' is once again facing dire financial crisis! The bank are threatening headmistress Camilla Fritton with closure. Her unorthodox doctrine of free expression and self empowerment is also under threat from new Education Minister Geoffrey Thwaits, an old flame of Camilla's who is determined to bring discipline and order to the anarchic school.

In true St Trinian style the girls are in a league of their own; smart, fearless and determined to defend the school they love to the end. They need to unite the warring girl gang cliques and come up with the cash fast to save the school.