"Derailed" is a suspense thriller about a successful ad exec and loyal family man Charles, (Clive Owen) meets an alluring and sexy woman (Jennifer Aniston) on his morning commute. Flirtation quickly escalates into passion. But this casual fling quickly turns dangerous when a violent criminal confronts and pulls them into a dangerous plot. Now with their entire lives thrown terrifyingly off-course, Charles must figure out how to turn the tables and somehow save their families.